All posts by keith

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Bookmarks for March 28th

  • Blocking ‘oh-glick-nack’ may improve long-term memory – O-GlcNAc's effects on one particular protein, CREB, got the scientists' attention. CREB is a key substance that turns on and regulates the activity of genes. Many of the genes in cells are inactive at any given moment. Substances like CREB, termed transcription factors, turn genes on. Hsieh-Wilson found that when O-GlcNAc attached to CREB, CREB's ability to turn on genes was impaired. When the researchers blocked O-GlcNAc from binding CREB, the mice developed long-term memories faster than normal mice.

    Could blocking O-GlcNAc boost long-term memory in humans?

    "We're far from understanding what happens in humans," Hsieh-Wilson emphasized. "Completely blocking O-GlcNAc might not be desirable. Do you really want to sustain all memories long-term, even of events that are best forgotten? How would blocking the sugar from binding to other proteins affect other body processes? There are a lot of unanswered questions. Nevertheless, this research could eventually lead to ways to improve memory."
    Tags: research science

  • Stand up: Your life could depend on it – Standing up more often may reduce your chances of dying within three years, even if you are already physically active, a study of more than 200,000 people published in Archives of Internal Medicine shows. The study found that adults who sat 11 or more hours per day had a 40% increased risk of dying in the next three years compared with those who sat for fewer than four hours a day. This was after taking into account their physical activity, weight and health status.
    Tags: health research science
thinking linking

Bookmarks for March 27th

  • Single antibody shrinks variety of human tumors transplanted into mice, study shows – Human tumors transplanted into laboratory mice disappeared or shrank when scientists treated the animals with a single antibody, according to a new study from the Stanford University School of Medicine. The antibody works by masking a protein flag on cancer cells that protects them from macrophages and other cells in the immune system. The scientists achieved the findings with human breast, ovarian, colon, bladder, brain, liver and prostate cancer samples.
    Tags: health research science
  • Aspirin: High or low dose following heart attack? – "We observed no difference between patients taking a high dose versus a low of aspirin as it relates to cardiovascular death, heart attack, stroke or stent thrombosis," said Payal Kohli, MD,

    cardiology fellow at BWH and researcher in the TIMI Study Group, who is the lead author on this study. "Interestingly, we did find a dramatic difference in practice patterns of physicians in North America compared to those in the rest of the world," Kohli said. "North American physicians prescribed a high dose of aspirin for two-thirds of all their patients, while the exact reverse was true of the rest of the world. International physicians prescribed a low dose of aspirin to more than two-thirds of their patients." Dr. Stephen D. Wiviott, a cardiologist at BWH and researcher in the TIMI Study Group, is the senior author on the study.
    Tags: health research

Art, comics

On the Desktop

Here’s a new comic I’m working on. Been penciling about 2 pages a day, and am 8 pages in. Hope to have it finished by the end of April. I’m plotting other stuff, too. Hope to have a bunch for MECAF.


General

Mini Vacation

So yesterday the Girlfriend (AKA my wife) took a day trip to Camden-Rockland, and stayed overnight at a B&B in Camden. See more about that here. Stopped at a yard sale, and I got these (they’re in rough shape, but will be fun to go through):

In Rockland we stopped at an antique store, and I got these:


That’s a 1930’s ink well(see Jenny’s post I linked to above for another pic) and a sterling silver pen nib holder (which works very nicely). Both nice additions to my collections.

thinking linking

Bookmarks for March 15th

thinking linking

Bookmarks for March 13th

  • Startram – Startram is based on existing maglev technology and basic physics. A motivated nation could build a startram system capable of launching 300,000 tons of payload into orbit for less than $40/kg. The infrastructure for a cargo-only version would cost on the order of $20 Billion to build and could be completed within 10 years. A people-capable version could be built for $60 Billion and be completed within 20 years. For more technical information, please visit the resources section.

    Startram will necessarily be an international program, otherwise the potential for a expensive and dangerous arms race between nations is too great. Therefore, the next great step in human civilization must come from you, the people. This is simply too important to leave up to individual nations and militaries.
    Tags: research tech space SF science